Simplesa® Nutrition is proud to offer the Neuro-Health Protocol for Parkinson’s disease.
Along with the Neuro-Health Protocol, Simplesa has developed several additional supplements to address specific signs and symptoms of Parkinson’s disease (PD). Together the Neuro-Health Protocol and the Recommended Additional Supplements are designed to work synergistically to help minimize the progressive nervous system deterioration caused by PD.
Selecting the right Neuro-Health Protocol Bundle and Additional Supplements for my PD.
The Neuro-Health Protocol has shown effectiveness in Amyotrophic Lateral Sclerosis (ALS) research with similar supplements and in anecdotal evidence in humans (ALSFRS scores and narrative reports from nearly 2,000 individuals following the Neuro-Health Protocol). The Neuro-Health Protocol works differently in everyone. Those who benefit from the Neuro-Health Protocol have reported that they live, walk, talk, breathe, speak, and function well and often for an extended period of time. Many individuals see improvements in symptoms and an improved quality of life. A smaller percentage sees small benefits or none at all.
The ingredients in the Neuro-Health Protocol’s AAKG+ Core Powder have been shown to provide benefits in several neurodegenerative diseases, including ALS and Parkinson’s disease. Research has shed light on how the combination of AAKG (Arginine Alpha-Ketoglutarate), GABA (Gamma-Aminobutyric Acid), CoQ-10 (Ubiquinol) and Niacin, found in Simplesa’s AAKG+ Core Powder, along with Liposomal Glutathione (GSH), Lipid Replacement Therapy (LRT) and other supplements, may enhance mitochondrial function and be an effective stand alone and co-therapies in the management of Parkinson’s disease (PD).
Selecting the right Neuro-Health Protocol Bundle and Additional Supplements for my PD.
For detailed information on the research paper and Scientific references used to establish Neuro-Health Protocol’s basis as an effective co-therapy for Parkinson’s disease, please CLICK HERE .
Here’s a brief summary of the key symptoms, causes and processes that lead to PD.
4 Main Symptoms of Parkinson’s Disease:(3)
1) Slowed Movement (Bradykinesia)
2) Postural Instability
3) Muscle Rigidity
4) Resting Tremors
Other Symptoms:
1) Secondary Motor Symptoms (4): Shuffling Gate, Speech Changes, Freezing and Dystonia (repetitive movements)
2) Non-motor Symptoms (5): Anxiety, Fatigue, Depression, Memory Impairment and Sleep Disturbances
What Causes Parkinson’s Disease (Pathophysiology):(6)
Parkinson’s disease (PD) is primarily associated with the gradual loss of cells in the substantia nigra of the brain. This area is responsible for the production of dopamine which is a chemical messenger (neurotransmitter) that transmits signals between two regions of the brain to coordinate activity. Dopamine allows the substantia nigra and the corpus striatum to communicate to regulate muscle activity.
If there is deficiency of dopamine in the striatum, the nerve cells in this region “fire” out of control. This leaves the individual unable to direct or control movements. This leads to the initial symptoms of Parkinson’s disease. In addition, reduced levels of cofactors for cellular mitochondrial energy production have been found in the majority of patients with PD (8).
Main Processes that Trigger PD and other Neurodegenerative Diseases:
1) Neuro-inflammation: (inflammation of your nerves) (7,8,9)
2) Oxidative stress: (damage to cells caused by free radicals) (7,8,9)
3) Aging process: (your genes and your environment affect your aging rate) (7,8,9)
4) Mitochondrial dysfunction: (cell’s inability to generate energy) (8,10)
5) Poor detoxification: (accumulation of heavy metals and toxins in your body)
Alternative Therapies and Supplementation:
Currently the main treatment and the cornerstone for PD’s drug therapy is L-dopa. This drug helps replenish the brain’s supply of dopamine, reducing tremors and other symptoms (11). As with any drug, medical supervision and gradual increase of the dosage is required. There are other drugs and treatments and we strongly recommend that any one diagnosed with PD seek immediate and ongoing medical care.
We do not offer a cure nor do we offer a guarantee of improvement of your PD symptoms. Nevertheless, Simplesa Nutrition has accumulated substantial expertise and credibility over the years in providing alternative treatments for ALS and other Neurodegenerative diseases. PD shares many similar root causes to ALS and is one of the diseases that shows most promise to benefiting from the Neuro-Health Protocol.*
The Neuro-Health Protocol has been proven beneficial to many Motor Neuron disease sufferers. We invite you to read the 100’s of positive reviews and testimonials of people who have found our products helpful. There is increasing scientific connection between PD and the use of supplements as an alternative and adjuvant therapy. As with any other co-therapy, please check with your physician for the final determination in the use of these supplements.*
Selecting the right Neuro-Health Protocol Bundle and Additional Supplements for my PD.
Using Supplements to help slow down the Main Processes that Trigger PD:
1) NEURO-INFLAMMATION: (inflammation of your nerves)
Neuro-inflammation is a complex response to brain injury involving the activation of glia (connective tissues of the nervous system), release of inflammatory mediators, such as cytokines and chemokines, and generation of reactive oxygen and nitrogen species.
Treatments:
a) Pain relief using OTC or prescription medications
b) Using varying combinations of corticosteroids, anti-inflammatories and nutritional supplements
Recommended Supplements*:
a) Niacin/Nicotinamide
b) Glutathione (GSH)
c) Hemp Oil
2) OXIDATIVE STRESS: (damage to cells caused by free radicals)
Oxidative stress occurs when there is an imbalance between the production of free radicals and the body's ability to counteract their damaging effects through neutralization with antioxidants. This is particularly damaging when this oxidative stress attacks neural cells.
Treatments:
a) Stop smoking, exercise more, avoid fatty foods and deep fried foods
b) Avoid chronic psychological stress and excessive drinking. Avoid Environmental toxins
c) Eat foods and take supplements rich in antioxidants
Recommended Supplements*:
a) Glutathione
b) Ubiquinol/CoQ-10
c) Vitamins A, B, C, D, E and Alpha-Lipoic Acid
3) AGING PROCESS: (your genes and your environment affect your aging rate)
Aging is commonly defined as the accumulation of diverse deleterious changes occurring in cells and tissues with advancing age that are responsible for the increased risk of disease and death.
Treatments:
a) Slow down your aging rate by improving your immunologic response and by reducing your mitochondrial oxidative damage.
b) Maintain a healthy diet and exercise regularly. Avoid smoking, excessive drinking, excessive stress, environmental oxidative stresses. Sleep well.
c) Avoid inflammation, excessive psychological stress, hypertension, etc.
d) Stay socially connected and intellectually stimulated.
Recommended Supplements*:
a) Arginine Alpha-Ketoglutarate (AAKG) and Gamma-Aminobutyric Acid (GABA)
b) Glutathione, CoQ-10
c) B-12, 5-HTP, Vitamins C, D and E
d) Hemp oil
e) Nicotanamide Riboside and Vinpocetine
4) MITOCHONDRIAL DYSFUNCTION: (cell’s inability to generate energy)
Mitochondrial dysfunction occurs when the mitochondria in our cells do not work as well as they should due to another disease or condition. This can affect almost any part of the body, including the cells of the brain, nerves, muscles, kidneys, heart, liver, eyes, ears or pancreas.
Treatments:
a) Increase mitochondrial energy production. Reduce oxidative stress.
b) Increase antioxidant intake. Increase vitamin, mineral and unsaturated fatty acids intake
Recommended Supplements*:
a) Arginine Alpha-Ketoglutarate (AAKG), Niacin, Lipid Replacement Therapy (LRT)
b) Vitamins C, D and E, thiamine, riboflavin and L-carnitine
c) Minerals like magnesium, calcium and phosphate
d) CoQ-10, Alpha Lipoic Acid, Nicotanamide Riboside, Glutathione
5) POOR DETOXIFICATION: (accumulation of heavy metals and toxins in your body)
Detoxification is the removal of metallic and non-metallic toxic substances from the body. Toxins and toxic metals including heavy metals like Arsenic, Cadmium, Lead and Mercury can build up and become a significant health hazard.
Treatments:
a) Chelation therapy (treatment that binds toxins in the bloodstream by circulating a chelation solution (a solution that binds to metals in the blood).
b) Lifestyle and dietary changes to avoid exposure to toxins
c) Exercise and healthy digestive functions
Recommended Supplements*:
a) Milk thistle, choline, inositol
b) Vitamins A, C D and E, Vitamin B Complex
c) Antioxidants, Glutathione
d) Probiotics
Selecting the right Neuro-Health Protocol Bundle and Additional Supplements for my PD.
Bringing it all together, the Neuro-Health Protocol for Parkinson’s disease:
| Main Processes that trigger PD | PD Symptoms | Recommended Additional Suplemts* |
| 1.- Neuro-inflammation |
Slowed Movement Speech Changes Memory Impairment |
Neuro-Boost |
| 2.- Oxidative Stress |
Muscle Rigidity Resting Tremors Pain, Speech Changes |
Total Health AM and PM |
| 3.- Aging Process |
Slowed Movement Postural Instability Fatigue, Depression Anxiety, Memory Impairment, Sleep Disturbances |
Total Health AM and PM Neuro-Boost |
| 4.- Mitochondrial Dysfunction |
Muscle Rigidity Resting Tremors Dystonia, Fatigue Depression, Speech Changes, Memory Impairment |
Total Health AM and PM Neuro-Boost |
| 5.- Poor Detoxification |
Slowed Movement Memory Impairment Fatigue, Digestive & Sleep Disturbances |
Neuro-Boost |
Selecting the right Neuro-Health Protocol Bundle and Additional Supplements for my PD.
* These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease.
References
- Ebadi M, et al. Ubiquinone (coenzyme q10) and mitochondria in oxidative stress of Parkinson’s disease. Biol Signals Recept. 2001 May-Aug; 10(3-4):224-53.
- Beitz, Janice. Parkinson's disease: a review. Frontiers in Bioscience. S6, (65-74), January 1, 2014.
- Weiner, William J. Parkinson's Disease: A Complete Guide for Patients and Families.The Johns Hopkins University Press: October 8, 2013; (4-5).
- Jancovic J. Parkinson’s disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry 2008;79:368-376 doi:10.1136/jnnp.2007.131045
- Calleo JS, et al. A Pilot Study of a Cognitive-Behavioral Treatment for Anxiety and Depression in Patients with Parkinson Disease. J Geriatr Psychiatry Neurol. 2015 Jun 4. pii: 0891988715588831.
- Ebadi M, et al. Ubiquinone (coenzyme q10) and mitochondria in oxidative stress of Parkinson’s disease. Biol Signals Recept. 2001 May-Aug;10(3-4):224-53.
- H, et al. Regulation of the Neurodegenerative Process Associated to Parkinson's Disease by CD4+ T-cells. J Neuroimmune Pharmacol. 2015 May 28. [Epub ahead of print]
- Gibson GE, Kingsbury AE, Xu H, et al. Deficits in a tricarboxylic acid cycle enzyme in brains from patients with Parkinson’s disease. Neurochemistry"International."2003; 43 (2):129D135. 129.
- Jia H, et al. High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinson's disease. J Neurosci Res. 2008 Jul;86(9):2083-90. doi: 10.1002/jnr.21650.
- De Rosa P, et al. Candidate genes for Parkinson disease: Lessons from pathogenesis. Clin Chim Acta. 2015 Jun 2. pii: S0009-8981(15)00277-6. doi: 10.1016/j.cca.2015.04.042. [Epub ahead of print]
- NIH. Parkinson's Disease: Diagnosis and Treatment. Winter 2014 Issue: Volume 8 Number 4 Page 8-10
- Weaver F, Follett K, Hur K, Ippolito D, Stern M. Deep brain stimulation in Parkinson disease: a metaanalysis of patient outcomes. J Neurosurg. 2005;103(6):956-967
- Dehay B, et al. Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations. Lancet Neurol. 2015 Jun 3. pii: S1474-4422(15)00006-X. doi: 10.1016/S1474-4422(15)00006-X. [Epub ahead of print]
- https://www.michaeljfox.org/foundation/grant-detail.php?grant_id=402
- Wang MS, et al. Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson's disease cell model. BMC Neurosci. 2010 Apr 30;11:57. doi: 10.1186/1471-2202-11-57.
- Tritsch NX, Ding JB, Sabatini BL. DOPAMINERGIC NEURONS INHIBIT STRIATAL OUTPUT THROUGH NON-CANONICAL RELEASE OF GABA. Nature. Oct 11, 2012;490(7419):262-
- Félix J. Jiménez-Jiménez, et al. Cerebrospinal fluid biochemical studies in patients with Parkinson's disease: toward a potential search for biomarkers for this disease. Front Cell Neurosci. 2014; 8: 369.
- Satpute R, et al. Neuroprotective effects of α-ketoglutarate and ethyl pyruvate against motor dysfunction and oxidative changes caused by repeated 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine exposure in mice. Hum Exp Toxicol. 2013 Jul;32(7):747-58. doi: 10.1177/0960327112468172.
- Shults CW1, Haas RH, Beal MF. A possible role of coenzyme Q10 in the etiology and treatment of Parkinson's disease. Biofactors. 1999;9(2-4):267-72.
- Jia H, et al. High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinson's disease. J Neurosci Res. 2008 Jul;86(9):2083-90. doi: 10.1002/jnr.21650.
- Gu F., Chauhan V., Chauhan A. Glutathione redox imbalance in brain disorders. Current Opinion in Clinical Nutrition and Metabolic Care. 2015;18:89–95
- De Blundel D., Schallier A., Loyens E., Fernando R., Miyashita H., Van Liefferinge J., Vermoessen K., Bannai S., Sato H., Michotte Y., Smolders I., Massie A. Loss of system xc- formula does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility. Journal of Neuroscience. 2011;31:3592–5803
- Dringen R., Pfeiffer B., Hamprecht B. Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione. Journal of Neuroscience. 1999;19(2):562–569